Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia.

نویسندگان

  • Jason D Maguire
  • Iwa W Sumawinata
  • Sofyan Masbar
  • Budhi Laksana
  • Purnomo Prodjodipuro
  • Ika Susanti
  • Priyanto Sismadi
  • Nurlis Mahmud
  • Michael J Bangs
  • J Kevin Baird
چکیده

Oral chloroquine is the treatment of choice for uncomplicated Plasmodium malariae infections worldwide. We did a prospective 28-day in-vivo assessment of the efficacy of chloroquine for treatment of P malariae on Legundi Island in Lampung Bay, Sumatra, Indonesia. Of 28 patients, one had recurrent parasitaemia on day 28, and two had persistent parasitaemia to day 8. Whole-blood chloroquine and desethylchloroquine concentrations were at ordinarily effective levels (> or = 100 microg/L) on day 8 in both cases of persistent parasitaemia. These findings suggest that clinical resistance to chloroquine by P malariae occurs in the Indonesian archipelago of southeast Asia.

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عنوان ژورنال:
  • Lancet

دوره 360 9326  شماره 

صفحات  -

تاریخ انتشار 2002